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The therapeutic window appears narrow

The interplay between c-Met and its ligand mediate downstream events that, in the central nervous system, play a critical role in cerebellar granule cell precursors proliferation and survival.Dysregulation of this pathway can promote tumorigenesis through cell migration, invasion and metastasis, angiogenesis and prevention ofapoptosis

In overdose, normal pathways for acetaminophen metabolism are saturated

doi: 10.1542/peds.2005-2440
