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Select a subcutaneous site in the abdominal fat pad, at least 2 cm lateral to the umbilicus

Histologically, epidermal thickening, severe hyperkeratosis, and epidermal acanthosis were seen ( Mll4 -knockout mice developed red, scaly skin ( Alox12 , Alox12b , and AloxE3 expressions were downregulated

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J Cardiovasc Pharmacol 79:759768
Although current reports indicate the effectiveness and benefits of collagen peptides in clinical treatments, more clinical trials and long-term controlled population studies are necessary to verify their role in delaying skin aging and to elucidate their mechanisms of action
