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The cellular damage inflicted by ROSs is influenced not only by their intracellular concentration but also by the balance between ROSs and endogenous antioxidant mechanisms
Furthermore, their quinidinelike effect on cardiac conduction, which can prolong the QTc interval, necessitates careful cardiovascular screening and often precludes their use in elderly patients or those with preexisting heart disease, frequently positioning them as a secondary choice after SNRIs or gabapentinoids [45, 336, 368, 369]
It ameliorates functional outcomes post-TBI
