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KD might protect from NAFLD through several mechanisms

(2016) 18(Suppl F):F21

At high concentrations, LA functions as an antioxidant, binds metals, and facilitates glucose uptake and utilization

A., Perry, N

To enable their transport, the carnitine shuttle system uses Acyl Carnitine Translocase to move Acyl CoA into the mitochondrial matrix , where -oxidation occurs

The direct influence of the E4 allele on FA-related bioenergetics (i.e., the transport and use of metabolites, in this case FAs, for energy) within the cerebrovasculature requires further attention, specifically in E4 carriers because of their increased cerebrovascular vulnerability observed with age which could impair nutrient transport to the brain and affect proper neuronal and glial functioning (Ojo et al., 2021)