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The 2022 BPPT provision will eventually replicate Orange Book-style patent linkage for biologics, materially changing how biosimilar developers plan Paragraph IV-equivalent challenges

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The progression is real but measured

Caspases are cysteine proteases that are inactivated by the oxidation of thiol groups to disulfides, as well as other proteins involved in cell survival are, such as NF-kB or c-Jun N-terminal kinases (JNK) [44]

Data Availability Statement The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.

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