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Journal of Nanoparticle Research, 19 (2), 41

Increased SOD2 activity weakens the accumulation of mitochondrial reactive oxygen species (ROS) in spatially constrained cancer cells, thereby supporting the survival of tumor cells in blood vessels in lung tissue and accelerating tumor metastasis in mice (68)

144 TarangeloA.MagtanongL.Bieging-RolettK

found activation of the polyol pathway and an upregulation of PARP-1 in the lungs of diabetic rats compared with nondiabetic animals, which correlated with increases in the NADH/NAD + ratio, the activities of mitochondrial respiratory complex IIV, and cellular ROS production (104), supporting the view that reductive stress occurs in the development of diabetic complications

Impact of dopamine oxidation on dopaminergic neurodegeneration