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It should be noted, however, that ALDH1A1, but not CYP2E1, is a downstream target of NRF2, which was found to be activated in untreated GCLM KO mouse liver

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In locus coeruleus neurons, cellular tolerance can be observed in brain slices prepared from animals treated with morphine for 3 days (Bailey et al., 2009a) and is reversed by administration of a PKC inhibitor

Medical Therapy : Corticosteroids : For nodules caused by inflammatory reactions, intralesional corticosteroid injections can help reduce inflammation and shrink the nodules