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loading large mRNAs remains the bottleneck, motivating EV-hybrid strategies (discussed in section 3.5) [73,74]

These properties make GDC a novel and ideal candidate for transiently inducing a leaky, infant-like epithelial phenotype, a previously unexplored approach for modeling early-life gut barrier function in vitro

[DOI] [PMC free article] [PubMed] [Google Scholar] 53.Gao, S

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This effect is mediated by inducing G0/G1 cell cycle arrest in SMMC-7721 hepatocellular carcinoma cells, upregulating the expression of p53 and Bax, and downregulating the expression of Bcl-2 in response to hypoxic conditions, thereby exerting a potent anticancer effect (Kim, 2023)