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These microbial metabolites are critical for Foxp3 + Treg expansion, histone deacetylase (HDAC) inhibition, and the suppression of NLRP3 inflammasome activation

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Meenatchi M, Vellapandian C (2024) Exploring the long-term effect of artificial sweeteners on metabolic health

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Scientific References European Journal of Endocrinology (1998) "Ipamorelin, the first selective growth hormone secretagogue." (The landmark study defining its selectivity)

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Conversely, the M2 phenotype is generally considered anti-inflammatory and has been associated with enhanced phagocytic activity, potentially reducing the risk of AD and its progression [99]

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