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These microbial metabolites are critical for Foxp3 + Treg expansion, histone deacetylase (HDAC) inhibition, and the suppression of NLRP3 inflammasome activation

Meenatchi M, Vellapandian C (2024) Exploring the long-term effect of artificial sweeteners on metabolic health

Scientific References European Journal of Endocrinology (1998) "Ipamorelin, the first selective growth hormone secretagogue." (The landmark study defining its selectivity)

Conversely, the M2 phenotype is generally considered anti-inflammatory and has been associated with enhanced phagocytic activity, potentially reducing the risk of AD and its progression [99]

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