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doi: 10.1038/s41568-019-0238-1

Mitochondrial Mg2+ homeostasis decides cellular energy metabolism and vulnerability to stress

Anti- ALPP/ ALPPL2 immunoconjugates can be formed by conjugating the antibodies or antigen binding portions thereof described herein to an effector (e.g., a detectable label, another therapeutic agent, etc.)

However, other mammals, such as guinea pigs and humans, have much higher levels of hepatic GGT (Hinchman and Ballatori, 1990, Hinchman et al., 1991, Hinchman et al., 1993, Hinchman et al., 1998), and therefore, metabolic pathways and trafficking of mercapturate intermediates may vary from species to species

& Yonkers, P

CHAC1 inactivation resulted in increased muscle glutathione levels under basal and wasting conditions