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In silico predictive modeling Based on the binding pose observed for THC in the X-ray structure, we used the program DOCK 28 to computationally predict binding geometries of the primary THC metabolite 11-OH-THC, secondary THC metabolite THC-COOH, the THC isomer CBD, and the cannabinoid analog AJA

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The current evidence base is animal-model-heavy and human-trial-light

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