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In the later stage of injury, the continuously high expression of MMP-9 not only hinders the normal reconstruction of ECM, but also the fragments produced by its degradation of ECM and the released/activated latent growth factors may instead promote the proliferation, migration and transformation into myofibroblasts of fibroblasts, driving the abnormal pathological fibrosis process ( 2.5.2 Hirsutanol A and fucoidan alleviate lung injury through the regulation of matrix metalloproteinase-9 (MMP-9) and fibroblast function Animal experiments have confirmed that in acute lung injury complicated with LPS-induced endotoxemia, Hirsutanol A (HA) derived from the Marine fungus Chondrostereum sp

doi: 10.1007/s00213-018-5024-3, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] Guan Y., Chen X., Zhao B., Shi Y., Han F

Chitosan, a natural polymer, exhibits favorable properties such as biocompatibility, non-toxicity, and biodegradability, making it a widely employed material for drug delivery [95]

Its gastric acid stability makes it a genuinely viable oral agent for GI applications an unusual capability among peptides

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Smad7 Protein Interacts with Receptor-regulated Smads (R-Smads) to Inhibit Transforming Growth Factor- (TGF-)/Smad Signaling