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In a Cochrane review, nine out of ten trials found that melatonin effectively reduced jet lag symptoms in travelers, especially if traveling eastward or over five time zones [74]

Moreover, an elevated Bax/Bcl-2 ratio is considered a critical factor in the degenerative pathology of dopaminergic neurons

10.1016/j.jep.2023.117226 194 YeZ.HuangW.LiJ.TangY.ShaoK.XiongY

Hepatology 38 , 11361145, doi: 10.1053/jhep.2003.50450 (2003)

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