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doi: 10.1007/s00223-008-9109-6

V.KuperJ.GeerlofA.von KriesJ

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Animal studies confirm TMAOs impact: serum TMAO increase correlated with impaired glucose tolerance in monkeys on HFD (150)

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Among other things, this is due to the fact that patients with pyruvate dehydrogenase deficiency are in a way dependent on food-derived glucose, as gluconeogenesis itself is impaired in these individuals [59]
