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FIGURE 4 4.1 Role of endogenous/enzymatic antioxidants Fortunately, the organisms body contains a free radical defense mechanism

The researchers observed a significant increase in glutathione (GSH) synthesis (approximately 85 percent) and a 64 percent rise in total GSH levels in red blood cells

Wang L, Hong G, Li D, Chen X, Han W, Lu Z

Ni F, Yu W-M, Li Z, Graham DK, Jin L, Kang S, Rossi MR, Li S, Broxmeyer HE, Qu C-K

Metformin, for example, suppresses the p62-KEAP1-NRF2 axis, blocking NRF2 nuclear translocation and improving sensitivity to sorafenib in both cell lines and xenograft models [41]

doi: 10.1186/1741-7015-7-25
