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Given this crucial definition, the abnormalities in hippocampal structure combined with the dysfunction of hippocampal neurogenesis observed in many mood disorders such as posttraumatic stress disorder (PTSD), major depressive disorder (MDD), borderline personality disorder (BPD) and bipolar disorder (BD) [26,27] could find an association with the impairment of proliferation in progenitor and neural stem cells and defects in the control of cell differentiation in the adult DG

Since growth hormone release is regulated by the hypothalamus and pituitary gland, any influence on these neural systems might indirectly affect testosterone production

doi: 10.1021/acs.jmedchem.0c01576

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Initial studies in animal models suggested that pineal peptide extracts containing the AEDG sequence might extend lifespan and improve various markers of aging