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Description
Mechanistic specificity
Theoretical and reported concerns Off-target cell death: no compound is perfectly selective, so healthy cells with temporarily high FOXO4 could be affected in theory
the corneocyte cells acting as the bricks, and the intercellular lipid matrix the mortar (Figure 4)
adipose epigenetic marks favor oxidative metabolism [2]
References Mitchell, W
In the USA and EU, AOD-9604 never achieved regulatory approval
