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246 In recent years, increasing evidence has shown that the PI3K/AKT signaling pathway is closely associated with the occurrence and development of UC and is also an important signaling pathway for targeted UC therapy

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[112] [113] Gluten-free diets have been shown in several studies to reduce antibodies, and in other studies to have no effect, however there were significant confounding issues in these studies, including not ruling out comorbid coeliac disease

The combined effect: even when dietary B12 intake is adequate, absorption from food can drop to a fraction of what it was at 40

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