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It is unclear why inhibition of c-MET by foretinib increased radiosensitivity, whereas inhibition with crizotinib appeared to have the opposite effect, though this phenomenon is likely due to other kinases targeted by these two molecules

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Pourmortazavi SM, Taghdiri M, Makari V, Rahimi-Nasrabadi M

Oppenheimer, Stacey R

The reason for occurring this phenomenon (reduction of CySGly- but not of GS-bound Mercury(II)) in solution and in the biological environment of cells is reasonably a consequence of the low reducing electrochemical potential of CySGly (at 0.282 V the most reducing one of the whole soluble physiological thiolome)

doi:10.1001/archinte.159.1.38