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found that patients with T2DM, hyperlipidemia, coronary artery disease, polycystic ovary disease (PCOD), or obesity, and on metformin therapy were significantly associated with increased risk of vitamin B 12 deficiency and lower serum vitamin B 12 concentrations [9]

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These methods fail to fully capture the intrinsic quality, efficacy, and safety of Chinese medicine, highlighting the need for more advanced biological evaluation techniques

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Future research should focus on exploring biomarkers that predict CDK4/6 inhibitor efficacy and screening sensitive populations