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In a recent similar study, depletion of Tfam also reduced mesoderm differentiation efficiency and the commitment of human PSCs to cell-lineages highlighting the regulatory role of mitochondria in cell-fate determination and demonstrating that any defects in the process could lead to fetal cardiac abnormalities [39]

Cholinergic Hypothesis The cholinergic hypothesis postulates that AD is caused by a reduction in acetylcholine synthesis in the brain

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Compared with those from the blank control group, the heart samples from the HUA group showed reduced CPT1B expression, especially in fields close to the endocardium (Figure 5E)

Landry et al., 2021b)

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