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Knockdown studies of GPX4 results in a reduction in the expression of genes encoding components of Complex I, IV, and V [53], while overexpression of mitochondrial GPX4 prevents release of the proapoptotic molecule cytochrome C from mitochondria, suggesting a key role as an anti-apoptotic agent in mitochondrial death pathways [26]

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doi: 10.1002/mds.28632

PLoS ONE 8:e62497 Klusek J, Nasierowska-Guttmejer A, Kowalik A, Wawrzycka I, Lewitowicz P, Chrapek M, Guszek S (2018) GSTM1 , GSTT1 , and GSTP1 polymorphisms and colorectal cancer risk in Polish nonsmokers

The ends of this U-shaped fiber run toward the poles of both capsular surfaces