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Given the role of choline in immune regulation, in this section of the review, we will discuss its role across various immune cell types

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Besides, abnormalities in the autophagy-lysosomal pathway (ALP) and the ubiquitin-proteasome system (UPS) of PD patients lead to the dysregulation of selective and targeted degradation of abnormal or misfolded protein species, such as -Syn, and cause an increased level of -Syn aggregations (Nguyen et al., 2019)

(PubMed) Berge G, Ovrebo S, Eilertsen E, Haugen A, Mollerup S

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Among these, SGLT2 inhibitors stand out as the most successful example, having advanced from mechanistic insights to multiple large-scale RCTs and guideline-recommended first-line therapy