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The unfolded protein response mediator PERK governs myeloid cell-driven immunosuppression in tumors through inhibition of STING signaling

doi: 10.3389/fendo.2024.1359685 149 Van BelleTLTaylorPVon HerrathMG

Neoplasma 69, 14061417 (2022)

220 Paez-EspinoDEloe-FadroshEAPavlopoulosGAThomasADHuntemannMMikhailovaNet al

Up to 29% of cases recur within five years after primary surgery, and only one third of CRC diagnoses are localized at the time of detection ( The persistently low survival rates and high recurrence of CRC can be attributed to cancers ability to develop resistance against existing therapies ( 2 Mechanisms of chemotherapy resistance in CRC 2.1 Resistance due to modulation of cell death pathways 2.1.1 Evasion of apoptosis Apoptosis is a natural process of programmed cell death, allowing for the regulation of homeostasis through the maintenance of normal cells and embryonic development ( p53 is a crucial tumor suppressor that responds to a variety of stress signals, including DNA damage and oncogene activation