foxo4-dri senolytic mouse 2023 2024 Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging: Cell Full article: Targeting Cellular Senescence

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doi:10.1056/NEJM198805123181902 14

Grunhagen, T., Shirazi-Adl, A., Fairbank, J

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Within each plexus, there are markedly different neuronal densities across species between the mouse, guinea pig, and human, and, interestingly, the total numbers of enteric neurons mirror the numbers of neurons in the spinal cord of these species (47)

It should be noted that expression of p16 actually increased after 3 days of ABT 263 treatment, indicating the potential stress of senolytics on cells