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doi: 10.1158/1055-9965.EPI-17-1136 240

Vitamin B6: a molecule for human health

More recent clinical trials have found no difference in comparison to a placebo (Javed et al., 2015)

77 VamecqJ.de HoffmannE.Van HoofF
While endogenous carriers like extracellular vesicles or biomimetic coatings are designed to minimize immune recognition, the introduction of targeting ligands, synthetic polymers, or residual manufacturing components can provoke unintended inflammatory or foreign body responses, potentially neutralizing the therapeutic effect or causing adverse events

A duck study used 300 to 1,500 mg/kg of L-theanine and reported 600 and 900 mg/kg as best supplementation levels to improve growth performance, immunity, intestinal morphology, and antioxidant status (Zhang et al., 2019b)
