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coli specifically bind to and alter the function of tight junctions, with consequent massive fluid and electrolyte secretion [81, 82]

In contrast, although effects on intracellular Ca 2+ levels have been reported both in sensory neurons, renal tubular cells and cancer cells, the contribution of Ca 2+ to cisplatin-induced neuropathy is relatively poorly understood

97,200,207,208 CYP2C9 can generate all of these metabolites, but other CYPs are specific for hydroxylation at single positions

& Leavitt, B

Subcutaneous injection near the injury site delivers high local concentrations while still providing systemic distribution through circulation

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