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Surgery can leave patients with IBD particularly prone to vitamin B12 deficiency due to anatomical changes that hinder absorption

Specifically, reduced IL-12 hampers Th1 cell differentiation and macrophage activation, reduced IL-2 compromises T-cell proliferation, and reduced IFN- impairs intracellular defense [19]

AACR Annual Meeting 2024 84(6), 2024
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Adequate levels of GSH are crucial in maintaining reduction-oxidation (redox) balance within body tissues with the ratio of reduced to oxidized glutathione (GSH/GSSG) being a primary indicator of redox state
