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At baseline, the urinary carnitine concentration was 103 M (IQR: 12125), peaking at 382 M (IQR: 125533) on Day 6

These types of infections impact the immune system and can become triggers for autoimmunity

In a suspected case of CPT II deficiency the following are considered: (1) dextrose infusion to prevent catabolism till special milk feeds can be arranged, (2) a high carbohydrate and low-fat diet to provide substrate for glycolysis, (3) avoidance of known triggers, e.g., fasting, illness etc., (4) urgent IEM screen/genetic testing/echocardiography/and ultrasound scan of the brain and kidneys, (5) MCT supplementation, (6) intensive care monitoring, and (7) a multidisciplinary team including metabolic specialists and palliative care doctors

Although brain cells have low levels of -oxidation, carnitine is actively transported across the bloodbrain barrier and accumulates in neural cells [1]

Brain Fog and Cognitive Dysfunction: The human brain is a highly energy-demanding organ, consuming roughly 20% of the body's total ATP