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Background Pyroglutamic acidosis is a rare cause of high anion gap metabolic acidosis
Dogs receiving high-calorie intake (120% MER) exhibited a dose-dependent reduction in feed consumption and significant body weight decrease at doses of 236 mg and 492 mg of L-carnitine, independent of exercise, and this was mostly found in females
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This article presents the current state of knowledge on mitochondrial damage mechanisms in HI and discusses potential therapeutic strategies, such as modulators of mitochondrial dynamics, antioxidant compounds, or inhibitors of specific mitochondrial pathways
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