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In cultured neurons, the replacement of glucose with BHB leads to changes in metabolic pathways, enhancing the TCA cycle flux, producing more -ketoglutarate, and ultimately converting to GABA in GABAergic neurons [38,195] (Figure 5A)
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Fyfe JC, Hemker SL, Venta PJ, Fitzgerald CA, Outerbridge CA, Myers SL, et al
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Biomaterials 27 , 335345 (2006)
The iron is stored in ferritin and further distributed to neurons
