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Innovative therapeutic avenues include enhancing the brain-targeted delivery of natural compounds (e.g., curcumin, resveratrol) to improve their anti-inflammatory and antioxidant efficacy, and engineering MSCs to continuously release anti-inflammatory factors for early-stage intervention in epileptogenesis

Regulation of melanogenesiscontroversies and new concepts

A deeper study has been conducted by Hossain and colleagues that defined an intricate molecular pathway of Cd-induced apoptotic cell death entailing ROS generation, Bax translocation and the consequent cytochrome C spillage from mitochondria, thus leading to cell death [182]

Favero FD, Basting RT, de Freitas AS, et al

There are multiple inputs into the TCA cycle but two important anaplerotic mechanisms are the conversion of pyruvate to mitochondrial OAA by pyruvate decarboxylase and the activation of glutaminolysis, which converts glutamine to glutamate and subsequently to -KG