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Additionally, plasma samples from mice collected 1 and 6 h after collection presented a decrease in UA monomers from 77.2 to 65.7%, accompanied by an increase in phase II metabolites (30), indicating that UA progressively forms conjugated metabolites after entering the plasma

138 , 139 These ligands must also be chosen in such a way that they can bind to target cells while avoiding healthy cells

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MitoQ, a mitochondria-targeted antioxidant, delays disease progression and alleviates pathogenesis in an experimental autoimmune encephalomyelitis mouse model of multiple sclerosis