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It often strikes people between the ages of 55 and 65

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Nitric oxide synthase in hypoxic or ischemic brain injury

The most important mechanisms of the hypertension are explained by the VEGF blockade inducing endothelial dysfunction resulting in the inhibition of VEGF-dependent vasodilatory pathways such as nitric oxide and prostacyclin, as well as the possible up-regulation of vasoconstrictive pathways such as endothelin-1

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