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Despite a dearth of comprehensive evidence for numerous pharmacological interventions, healthcare providers have turned to symptomatic treatments to mitigate a spectrum of issues, including psychological distress like anxiety and depression, emotional volatility (pseudobulbar affect), involuntary muscle twitches, pervasive fatigue, sleep disturbances, and a range of physical discomforts from muscle cramps and spasms to immobility-induced musculoskeletal pain, neuropathic pain, sialorrhea, spasticity, constipation, and urinary urgencies

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et al., 2020

A primary mechanism underlying this toxicity is oxidative stress, evidenced by increased lipid peroxidation (malondialdehyde MDA) and depletion of antioxidant defenses (superoxide dismutase SOD) within reproductive tissues, leading to inflammation and cellular damage 7

This process involves the stimulation of IGF-1 receptor hypertrophy and nitrogen retention, which are crucial for the development and enlargement of muscle fibers

Antioxidant system components The state of the antioxidant system reflects the capacity of the cell to resist ferroptosis