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Host-directed therapies have shown promise in preclinical studies

Too low body weight, intense exercise, chronic diseases, malabsorption disorders such as celiac disease, hyperthyroidism, and thus energy deficiencies lead to impaired pulsatile GnRH secretion, and as a result, the concentration of LH and FSH necessary for effective stimulation of the gonads is too low (51)

doi: 10.1038/mi.2016.42

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I find that magnesium citrate or magnesium glycinate often work best, but avoid the citrate if your child tends to have loose stools

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