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Importantly, BPC-157 shows no direct angiogenic effect on endothelial cell cultures, suggesting its pro-angiogenic activity requires the context of injury and healing responses present in vivoa safety feature that may limit unwanted neovascularization in healthy tissues

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These efforts are supported by GMP-aligned processes and third-party testing

Shear stress may also regulate apoptosis in ECs through cytochrome C release from mitochondria 37 and trophoblast-induced EC apoptosis 38 or via PI3K/Akt-dependent signaling 39