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The Thiamine deficiency results in lesions on the brain that can cause confusion, short term memory loss, ataxia, and other unpleasant symptoms

J Diabetes Complications 2018;32:171-8

Jacques Blanchette, Tyler County Emergency Management [48] The BeaumontPort Arthur metropolitan area also experienced torrential precipitation, including 32.55 in (827 mm) of rainfall in Beaumont

Withdraw the needle and you're done

So, going well over what the RDI dictates is non-negotiable, especially when it comes to seniors over 65 who will experience a decline in absorption rates as they age

I haven't read enough about those exact cases, I would suspect that it's at higher doses, but I'm not sure about that