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Research has shown that T-cell GPX4 deficiency can induce ferroptosis and inhibit T-cell proliferation (4)

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CYT-6091 clinical trials started in 2005 for delivery of recombinant TNF- as an anticancer therapy in late-stage pancreatic, breast, colon, melanoma, sarcoma and lung cancer patients

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J Transl Med 18:100 Lin T-N, Cheung W-M, Wu J-S, Chen J-J, Lin H, Chen J-J, Liou J-Y, Shyue S-K, Wu KK (2006) 15d-prostaglandin J2 protects brain from ischemia-reperfusion injury

This indicates that SMARCA4 deficiency reduced open chromatin at the promotor and enhancer regions of the SLC7A11 locus, thereby attenuating transcription of SLC7A11