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15 Although there exists considerable sequence similarity, the sensitivity of these two enzymes to their inhibitor malonyl-CoA differs greatly (CPTIA has a tenfold higher Ki for malonyl-CoA), 15 which makes CPTIA the more prevailing enzyme that accomplishes the rate-limiting step in -oxidation

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By contrast, low doses (0.5 mg/kg) administered intermittently for therapeutic purposes are considered relatively safe in the short term but may still pose risks with repeated use (Smith-Apeldoorn et al., 2022)

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