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Capsaicin induces heme oxygenase-1 expression in HepG2 cells via activation of PI3K-Nrf2 signaling: NAD(P)H:quinone oxidoreductase as a potential target

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By blocking System Xc or impeding the glutamate metabolic pathway, more ROS-induced lipid peroxidation and ferroptosis are triggered ( Erastin and RSL3 are two well-known compounds that induce ferroptosis ( via System Xc and to inhibit GPX4, respectively ( Figure 1 )