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It plays a vital role in protecting normal cells from reactive oxygen species (ROS) produced during many intracellular pathogens infections
Covalent modifications to histone tails, including methylation, acetylation, ubiquitination, sumoylation, citrullination, and phosphorylation, are well-correlated with chromatin structure (euchromatin versus heterochromatin) and accessibility, which in turn impacts transcriptional activation/silencing
Thorax 68 , 738745 (2013)
The citicoline brain injury treatment (COBRIT) trial: design and methods
Our group demonstrated that PNPLA3 is a novel binding partner of ABHD5 in BAT, functioning to compete with PNPLA2 for binding to ABHD5, thereby inhibiting adipocyte lipolysis (70)
Collectively, these strategies mitigate Fe-induced oxidative damage and help maintain root and shoot growth under toxic Fe 2 levels
