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1 Original Procognitive Characterization McCoy et al., Journal of Pharmacology and Experimental Therapeutics (2013) This paper has been under Expression of Concern since 2021 (see disclosure block above)

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However, the effects are typically shorter-lived than B12 shots, with most people scheduling treatments every few weeks to maintain optimal vitamin levels

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[vi] To determine the maximum starting dose, it has recommended converting the no observed adverse effect levels (NOAELs) from the conducted animal studies into human equivalent doses (HEDs) using standard factors