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These bubbles can disrupt recordings by knocking cells as they exit into the bath chamber, causing artefacts, loss of seal in patch recording, or complete loss of cells from the field of view in imaging and edge-detection experiments

Although prospective or randomized designs provide stronger control over confounding factors, logistical constraints and ethical considerations limited their feasibility in this setting

If the provided concentrations of the actives are high enough, and the topical product is repeatedly applied as a leave-on product, like in the current study, we believe that sufficient amounts of actives reach the hair bulb

Wick et al., 2004)