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PACCs are large, multinucleated cells that are thought to help mediate resistance and metastasis and are generated usually by a stressor, such as chemotherapy or hypoxia (Illidge et al., 2000

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Extended Half-Life vs Native -MSH Native -MSH has a plasma half-life of only a few minutes

Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible

All share a common core domain structure consisting of four EF hand repeats, a TIM barrel catalytic domain, separated into X and Y domains connected by a flexible X/Y insert linker, and a C2 domain (Kadamur and Ross, 2013)

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