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In silico docking confirmed strong binding affinity of PDSE-derived rutin and quercetin with caspase-3, further supporting their role in apoptosis induction ( Mangifera pajang (a lesser-known mango species) kernel extract showed cytotoxicity in both hormone-dependent (MCF-7) and triple-negative (MDA-MB-231) BC cells, with IC50 values of 23 g/mL and 30.5 g/mL, respectively

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These compounds have low activation energy to donate the hydrogen atom and, therefore, cannot initiate the secondary free radicals

Orlowski JP, Hanhan UA, Fiallos MR

Superoxide Dismutases and Superoxide Reductases