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Estimulacin de la va de sntesis de protenas PI3K/Akt/mTOR: Tras la activacin del receptor, el IGF-1 LR3 desencadena cascadas intracelulares, incluyendo la fosforilacin de PI3K y Akt

& Fuhrman, J

demonstrated that a subset of PC9 lung cancer cells can adopt an NRF2-active program in response to osimertinib, a third-generation EGFR tyrosine kinase inhibitor, characterized by enhanced glutathione metabolism, antioxidative response, and a shift to fatty acid metabolism [56]

[DOI] [PMC free article] [PubMed] [Google Scholar] 6

Theres less variability compared to nasal absorption, which can be affected by nasal congestion, individual anatomy, or administration technique

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