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Oxidation in small-molecule drugs often involves free radical-mediated autocatalytic reaction initiated by the abstraction of hydrogen from the carbon next to a heteroatom, followed by reaction with oxygen to form a peroxide free radical

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EHMES-1 cells were stimulated by the respective dimeric macrocycles and the phosphorylation level was quantified by enzyme-linked immunosorbent assay (ELISA) using a rabbit pY1234/1235-specific mAb

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