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doi:10.1002/anie.200300573

Hepatology 14(1):1015 Duthie SJ, Grant MH (1989) The toxicity of menadione and mitozantrone in human liver-derived Hep G2 hepatoma cells

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discovered that epigenetic silencing of RIPK3 in hepatocytes prevented liver damage caused by MLKL-mediated necroptosis

* Correspondence: Xianghong Huang, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
This circadian divergence may account for the disconnect between promising preclinical results and failed clinical outcomes in antioxidant trials, emphasizing the need for more sophisticated translational approaches that account for temporal biology in both animal studies and human applications
