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The mice were sacrificed after 3 weeks, and the heart, liver, spleen, lung, kidney and bladder of the mice were harvested for further study

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However, adverse reactions limit their use (Spagnolo et al., 2018)

They can be a suitable option for postmenopausal women in whom surgery is contraindicated due to other medical conditions

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Notably, the enzyme L-galactono-1,4-lactone dehydrogenase (GLDH), crucial in the final step, is located in the mitochondrial inner membrane, indicating mitochondrial involvement in AsA synthesis